Synthroid — L-thyroxine - Description and Recommendations
Buy synthroid online - the most frequently used name (USA) Sodium levothyroxine medicine. In particular, this thyroid hormone produced synthetically, which has the same effect as that of the endogenous hormone thyroxine-4 (T-4). Thyroid hormones are primarily responsible for the regulation of the rate of metabolism and play an important role for the human body. When administered hormones thyroid, metabolism is improved considerably. This is reflected in a faster conversion of carbohydrates, proteins and fats as the body burns more calories per day. For medical purposes, these hormones are used to treat disorders of the thyroid gland and obesity (caused by such breach).
This drug acts in much the same way as the drug Cytomel (Cytomel a). Cytomel, however, has a slightly different structure, as a synthetic hormone triidotironinom (T-3). In a healthy human body in a sufficient amount of both thyroid hormone T-3 and T-4. If they compare, then, roughly speaking, the hormone T-3 to 4 times stronger than that of T-4 (mainly T-4 hormone acts upon transformation into T-3). This becomes clear when one compares the release tablet form. Cytomel micrograms contains less material. The drug Cytomel is much stronger than Synthroid, and usually at the same accessibility prefer to buy it. Since Synthroid much weaker athlete must take it for a longer time to achieve the same result.
Thyroid hormones are among the most efficient in the arsenal of an athlete. When taking the drug fats are broken down more quickly, and the muscles become more prominent. As the body burns more calories during treatment, the diet becomes less relevant. This is especially important during the competition, since muscle mass suffering, when the body is not getting enough nutrients. The use of hormone allows the athlete to burn fat by consuming enough calories per day. Anabolic steroids are usually used in conjunction with these hormones as well as improving metabolism leads to rapid muscle growth (better absorbed by proteins). Because of this, some use of thyroid hormones during unplanned muscle building cycles, wanting to increase muscle mass, while not accumulating a lot of fat.
With this drug, as with all thyroid medications, the dose necessary to increase slowly and gradually. Typically, athletes start with a dose of 25-100 mg (1 / 4-1 100mcg tablet) and slowly increased to 25-50 mg daily or every other day. The last dose should not exceed 200-400 g (2-4 100 mg tab.). With hormones the thyroid gland there is always a risk of changes in the metabolic process in the use of too large doses or with prolonged use. We must be careful not to exceed the dose and not to use the drug longer than 6-8 weeks. For this reason it is important to reduce the dose gradually at the end of the cycle, as well as increased. It is recommended to reduce the dose by 25-50 mg in 1 or 2 days. The body gets used to the change in hormone levels, and you will avoid "shock", which is possible with a sharp termination.
When you receive a number of possible Synthroid side effects, which include trembling, excessive sweating, diarrhea, insomnia, nausea, rapid heartbeat, internal fatigue and weight loss. Minor side effects can be avoided by reducing the daily dose. If side effects are concerned, you need to stop taking the drug. Sudden interruption of taking the drug may aggravate the situation, so it is advisable to discontinue use of the drug gradually as possible. To avoid serious problems before taking the drug is better to consult a doctor to check your thyroid function. When hyperthyroidism should not take the drug.
Although L-thyroxine widely produced, it is not often to be found on the black market. Most likely, this is due to the fact that usually prefer more powerful Cytomel or Bole weak Triakanu. If, however, find this drug, you doubt its authenticity is almost should not be.
The synthesis and secretion of hormones regulated by the hypothalamic-pituitary-thyroid axis. Thyrotropin? follicle-stimulating hormone (TRH) released from the hypothalamus stimulates secretion of thyrotropin stimulating hormone, TSH, from the anterior pituitary gland. TSH in turn, is a physiological stimulus for the synthesis and secretion of thyroid hormones, L-thyroxine (T4) and L-triiodothyronine (T3), the thyroid gland. Circulating serum T3 and T4 levels exert a feedback effect on TRH and TSH secretion. When serum T3 and T4 levels increase, a decrease in the secretion of TRH and TSH. When thyroid hormone levels decrease, TRH and TSH secretion increase.
The mechanisms by which thyroid hormones exert their physiologic actions are not completely understood, but believed that their main effects is through the control of DNA transcription and protein synthesis. T3 and T4 distributed in the cell nucleus and bind to thyroid receptor proteins to DNA. This hormone nuclear receptor complex activates gene transcription and synthesis of messenger RNA and proteins, cytoplasmic.
Thyroid hormones regulate multiple metabolic processes and play an important role in normal growth and development and maturation of normal and central nervous system and bone. Metabolic actions of thyroid hormone include increase cellular respiration and thermogenesis, as well as the metabolism of proteins, carbohydrates and lipids. The protein anabolic effects of thyroid hormones are important for normal growth and development.
The physiological actions of thyroid hormone produced mainly T3, the majority of which (about 80%) is derived from T4 deiodination in peripheral tissues.
Levothyroxine is, at doses individualized according to patient response, acting as a substitute or adjunctive therapy in hypothyroidism of any etiology, except transient hypothyroidism during the recovery phase of subacute thyroiditis.
Levothyroxine is also effective in the suppression of pituitary TSH secretion in the treatment or prevention of various types of euthyroid goitre, including thyroid nodules, Hashimoto's thyroiditis, and goiter patients as adjunctive therapy in the management of thyrotropin-dependent well-differentiated thyroid cancer (sm. Indications and Usage, precautions and DOSAGE aND aDMINISTRATION).
Absorption of orally administered T4 from the gastrointestinal tract (GIT) is from 40% to 80%. Most of the levothyroxine dose is absorbed from the upper jejunum and ileum. Relative bioavailability of Synthroid tablets, compared to an equal nominal dose of oral levothyroxine sodium solution? approximately 93%. T4 absorption increased by fasting and decreased in malabsorption syndromes and certain foods such as soy infant formula. Dietary fiber decreases bioavailability of T4. Absorption may also decrease with age. In addition, many drugs and foods affect the uptake of T4 (see PRECAUTIONS -. Drug Interactions and Drug Interactions-Food).
Circulating thyroid hormones, more than 99% bound to plasma proteins, including thyroxine-binding globulin (TBG), thyroxine binding prealbumin (TBPA) and albumin (SA), whose features and similarities vary for each hormone. Above the proximity of GTE and TBPA T4 partially explains the higher serum levels, slower metabolic clearance, and longer half-life of T4 compared to T3. In the reverse equilibrium with small amounts of free hormone, there are protein bound thyroid hormones. Only free hormone is metabolically active. Many drugs and physiologic conditions affect the binding of thyroid hormones to serum proteins (see PRECAUTIONS -. Drug interactions and drug-laboratory test interactions). Thyroid hormones do not readily cross the placental barrier (see PRECAUTIONS -. Pregnancy).
Gradually eliminating T4 (see. Table 1). The main hormone metabolism is through sequential deiodination. Approximately 80 percent of the circulating T3 is derived from peripheral T4 monodeiodination. The liver is the primary site of degradation of T4 and T3, with T4 deiodination, also occurs in several other places, including the kidneys and other tissues. Approximately 80% of the daily dose of T4? deiodinated bring the same amount of T3 and reverse T3 (rT3). T3 and rT3 are further deiodinated for diiodothyronine. Thyroid hormones are also metabolized via conjugation with glucuronides and sulfates and excreted directly with them in the bile and gut where they undergo enterohepatic recirculation.
Thyroid hormones, especially kidney removed. Part of the conjugated hormone reaches the colon unchanged and is eliminated in the feces. Approximately 20% T4 is eliminated in the stool. With age, decreased urinary excretion of T4.