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Salsalate Seems Effective for Type 2 Diabetes

03/24/2010 - News

Salsalate Seems Effective for Type 2 Diabetes

By: June Chen, MD

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Salsalate is an anti-inflammatory drug that is commonly used for rheumatologic conditions. Small studies have shown that salsalate can also decrease blood glucose concentrations. Now, according to a study published in the March 16, 2010 issue of Annals of Internal Medicine, researchers report that treatment with salsalate lowers hemoglobin A1c (HbA1c) levels in people with type 2 diabetes.

Investigators for the Treating Inflammation Using Salsalate in Type 2 Diabetes (TINSAL-T2D) Study Team recruited patients with type 2 diabetes who were treated with diet, exercise, and oral medications at stable doses for at least 8 weeks. Study participants were randomized to receive 14 weeks of treatment with either placebo or salsalate at various doses, in addition to their current therapy. The researchers found the higher proportions of patients in the salsalate treatment groups experienced decreases in HbA1c levels of 0.5% or more from baseline compared to placebo. Other markers of blood sugar control also improved in the salsalate-treated patients. Mild hypoglycemia was more common with salsalate, and documented events occurred only in patients on concurrent sulfonylurea therapy.

These findings suggest that inflammation does, in fact, play a role in the pathogenesis of type 2 diabetes and anti-inflammatory therapy such as salsalate could be a useful treatment modality. Based on this relatively small study, salsalate may provide a new treatment option for patients with type 2 diabetes. However, renal and cardiac safety of salsalate require further evaluation.

 

Source:

Ann Intern Med 2010; 152: 346-357.

 

Created on: 03/24/2010
Reviewed on: 03/24/2010

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