ADVERTISEMENT

This site is intended for non healthcare professionals. For the professional site, please click here

09/09/2009 - News

Combination Lipid Therapy No Better Than Statins

By: June Chen, MD

Tools:

Cholesterol-lowering therapy with statins effectively prevents cardiovascular disease, but treatment with statins does not guarantee that cholesterol targets are reached. In cases where intensive lipid-lowering is needed, physicians sometimes combine statins with other lipid-modifying medications. However, according to a review published online before print September 1, 2009 in Annals of Internal Medicine, limited evidence suggests that combinations of lipid-lowering agents do not improve clinical outcomes more than high-dose statins alone.

Researchers from the University of Ottawa in Ontario, Canada and their colleagues reviewed 102 studies to compare the benefits and harms of high-dose statins versus combination lipid-lowering therapy in adults at high risk for coronary artery disease. They found very-low-strength evidence that combination lipid-lowering therapy did not reduce mortality more than high-dose statins, though two trials did show that combination therapy was more likely to attain cholesterol-lowering goals.
 
Overall, the researchers found no benefit for combination lipid-lowering therapy over high-dose statins for mortality, heart attack, stroke, or the need for a revascularization procedure. However, a limitation of the review was that most of the studies reviewed were short. Further research is needed to see if there is a difference in clinical outcomes between combination lipid-lower therapy and high-dose statins in the long term.
 

Source:

Ann Intern Med. Published online before print September 1, 2009.

Created on: 09/09/2009
Reviewed on: 09/09/2009

Your rating: None Average: 5 (1 vote)
Tools:

Add your comment

  • Allowed HTML tags: <em> <strong> <cite> <ul> <ol> <li> <dl> <dt> <dd>
  • Lines and paragraphs break automatically.

More information about formatting options

CAPTCHA
This question is for testing whether you are a human visitor and to prevent automated spam submissions.
Image CAPTCHA
Copy the characters (respecting upper/lower case) from the image.